Findings from the CRAVE trial presented by Gregory M. Marcus, MD, MA, FACC revealed that coffee consumption resulted in more premature ventricular contractions (PVCs) and less sleep, but no increase in atrial arrhythmias and an increased amount of physical activity.
The trial enrolled 100 adults with median age of 38 years of which 51% were women and 48% were non-Hispanic White. Each participant was fitted with a continuously recording ECG device, a continuous glucose monitor and a Fitbit. Participants were randomized to consume or avoid coffee each day for 14 days and received daily texts and reminders. Overall results found random assignment to coffee consumptions was associated with
54% increase in PVCs
36 fewer minutes of sleep per night
1,058 additional Fitbit-based steps per days.
Each additional cup of coffee was associated with 3% more daily premature atrial contractions and 18 fewer minutes asleep per night. No significant differences in glucose levels and no increase in atrial arrhythmias were observed. Researchers did note that faster caffeine metabolizers experienced heightened PVCs, while slower caffeine metabolizers experienced the greatest impact on sleep.
Those who prone to PVCs or ventricular arrhythmias may benefit from coffee abstinence, but also noted that genetic differences influence risk. Additionally, he cautioned that while findings did show coffee consumption enhanced overall physical activity