The most predictive parameters of poorer health at age 65 were cardiovascular disease, clinically significant depressive symptoms, and current smoking. Osteoarthritis, lower education level, and higher body mass index (BMI) also were associated with poorer health status 10 years. Determining a patient's score on a health-related quality of life measure based on these variables might be useful in clinical practice to recognize midlife patients at increased risk for later health deterioration. This measure is called the Short Form 36 (SF-36), and the researchers specifically focused on the physical component summary score (PCS) of this measure. The SF-36 is similar to the Framingham 10-year coronary heart disease risk prediction score.

Over 10 years, 206 (18.9%) of the women in the study experienced clinically important declines of at least 8 points in baseline characteristics at around age 55. The following were significantly associated with these declines:

  • Having a higher BMI.

  • Having osteoarthritis.

  • Having a lower educational level.

  • Being a current smoker.

  • Having clinically significant depressive symptoms.

  • Having cardiovascular disease.

  • Having better (or higher) physical health and function score on the PCS.

Those with health declines were more likely to be Black and less likely to be Japanese. They were also more likely to have other comorbidities such as diabetes, hypertension, and osteoporosis, and to report less physical activity.



Disease Condition ,Risk factors-comorbidities,Hypertension,Metabolic and Mixed disorders,Behavioral stress